Summary: Osteoarthritis-Biomarkers levels are higher at 2 years follow up in patients with ACL-R, specifically in those above 24 years old, females treated in the first year from injury, associated meniscal injury and chondral lesions > grade 2. Special considerations must be taken to reduce OA-Biomarker concentrations and avoid early OA in these subgroups.

Purpose.
To describe OA-Biomarkers behavior according to risk factors for OA progression, in patients with ACL-Reconstruction, at 2 years follow up.

Methods.
Two OA-Biomarkers were evaluated (U-CTx-II / S-MMP-3) in 40 patients with ACL injury (mean age=26 years old). Pre-op and 2-year post-operative determinations were performed by ELISA. Descriptive analysis and non-parametric tests, were carried out to look for changes in these biomarkers and also identify any relation with age, sex, meniscal and chondral injury, and time from injury to reconstruction.

Results.
Significative higher concentrations were found in both OA-Biomarkers at 2 years. Patients above 24 years old, had higher levels in both biomarkers (U-CTx-II: p=0.003; S-MMP-3: p=0.001). Also, males had significant increase at the second measurement (U-CTx-II: p=0.01; S-MMP-3: p=0.008). Regarding time from injury to reconstruction, Spearman correlation test, was significative but negative in females before reconstruction and at 2 years follow up, (r=-0.55, p=0.04; r=-0.73 p=0.01, respectively). Meniscal injury presence, showed an increment in both biomarkers (U-CTx-II: p=0.001; S-MMP-3: p=0.01). Dividing the population by ICRS classification; males with cartilage lesions greater than grade 2 had higher concentrations at two years, despite of being non-statistically significative. Those who did not have an initial cartilage lesion had higher increase in biomarkers at 2 years.

Conclusions.
Despite ACL-R higher levels of OA-Biomarkers will persist at 2 years follow up, which could indicate that the reconstruction may represent a “second hit” to knee joint, especially in those over 24 years old, women treated in the first year from injury, associated meniscal injury and males with chondral injury > grade 2. These subgroups must be treated differently in a near future or look for treatment options to reduce OA-Biomarker concentrations and avoid early OA.

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Today’s Nonagenarians: Too Old for Arthroplasty? Abstract Presentation 6 minutes Stephen Sizer, DO, UNITED STATES Adam Rosen Julie McCauley, MPHc, UNITED STATES William Bugbee, MD, UNITED STATES
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Reliability And Agreement Between MRI And X-Ray For Measuring Caton-Deschamps Ratio ePoster Presentation Ryan W. Paul, BS, UNITED STATES Joseph Michael Brutico, BS, UNITED STATES Maggie Wright, MD, UNITED STATES Brandon Erickson, MD, UNITED STATES Fotios P. Tjoumakaris, MD, UNITED STATES Kevin Freedman, MD, UNITED STATES Meghan E. Bishop, MD, UNITED STATES
Wearable System Embedding Flexible Textile-Based Strain Sensor For Monitoring Knee Joint ePoster Presentation Umile Giuseppe Longo, MD, MSc, PhD, Prof., ITALY Arianna Carnevale, Eng, ITALY Carlo Massaroni , Eng, ITALY Emiliano Schena, Eng, ITALY Joshua Di Tocco, Eng, ITALY Vincenzo Candela, ITALY Alessandra Berton, MD, ITALY Giuseppe Salvatore, MD, PhD, ITALY Vincenzo Denaro, MD, PhD, Prof., ITALY
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Biomechanical Evaluation Of Two Non-Anatomic Patellar Fixation Techniques In Medial Patellofemoral Ligament Reconstruction ePoster Presentation Vasileios Raoulis, MD, PhD, GREECE Apostolos Fyllos, MD, PhD, GREECE Maria Dimitra Chiotelli, Dipl.Εngineer, GREECE Alexis Kermanidis, Prof, GREECE Vasileios Mitrousias, MD, PhD, GREECE Michael E. Hantes, MD, PhD, Prof., GREECE ARISTIDIS ZIBIS
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Management of First-Time Patellar Dislocation: A Survey of Prism Members ePoster Presentation Shital N. Parikh, MD, UNITED STATES Matthew William Veerkamp, BA, UNITED STATES PF RIG, UNITED STATES
Satisfactory Results Using A Novel Technique For The Fixation Of Posterior Lateral Meniscus Root In Acute Lesions With Concomitant Anterior Cruciate Ligament Injuries. ePoster Presentation German Alejandro Jaramillo, MD. Ortopaedic Surgeon, Sport Med, COLOMBIA Ruben Dario Arias Perez, MD, BS, COLOMBIA Esteban Arrubla-Rojas, MD, COLOMBIA
Athletes Cope Better Than Non-Athletes Before Knee Cartialge Surgery; A Prospective Cohort Study ePoster Presentation David C. Flanigan, MD, UNITED STATES Joshua Scott Everhart, MD, MPH, UNITED STATES Alex C. Dibartola, MD, MPH, UNITED STATES Eric Milliron, BS, UNITED STATES Laura C. Schmitt, PT, PhD, UNITED STATES Robert A Magnussen, MD, MPH, UNITED STATES Charles Emery, PhD, UNITED STATES
Lower Extremity Alignment in Professional Soccer Players Abstract Presentation 5 minutes Spencer M. Stein, MD, UNITED STATES William Tyler Haselman, BS, UNITED STATES Bert Roland Mandelbaum, MD, DHL(Hon), UNITED STATES
Isolated Medial Patellofemoral Ligament Reconstruction for the Treatment of Acute or Recurrent Patellar Instability: a Systematic Review and Meta-Analysis ePoster Presentation Maarten Mertens, MD, BELGIUM Peter Mertens, MD, BELGIUM K Buedts, BELGIUM Michael Maes, Md, BELGIUM
Short Term Results After Missouri Osteochondral Preservation System For Symptomatic Chondral Lesions ePoster Presentation Deryk G. Jones, MD, UNITED STATES Bhumit Desai, MD, UNITED STATES Emmanuel Koli, MD, UNITED STATES Gerard Karl Williams Jr., MD, UNITED STATES
Performing A Concomitant Tibial Tubercle Osteotomy During Primary Medial Patellofemoral Ligament Reconstruction Does Not Lead To Increased Post-Operative Complication Rates Abstract Presentation 5 minutes Adam Money, MD, UNITED STATES Seth L. Sherman, MD, UNITED STATES Kunal Varshneya, BS, UNITED STATES Andrew Gudeman, MD, UNITED STATES Kevin G. Shea, MD, UNITED STATES
A New Protocol For Obtaining Whole Leg Radiographs With Excellent Reproducibility Abstract Presentation 6 minutes Chien Nguyen, MSc., NETHERLANDS Nienke Van Egmond, MD, PhD, NETHERLANDS Mario Hevesi, MD, PhD, UNITED STATES Harrie Weinans, Prof., PhD, Ir. , NETHERLANDS Willem Paul Gielis, MD, NETHERLANDS Roel J.H. Custers, MD, PhD, NETHERLANDS
Comparison Of Outcomes For Medial Collateral Ligament Repair Versus Reconstruction: A Systematic Review ePoster Presentation Edward Floyd, MD, MS, UNITED STATES Kari L. Falaas, BS, UNITED STATES Nicholas J. Ebert, BS, UNITED STATES Griffin D. Struyk, BS, UNITED STATES Gregory B Carlson, MD, UNITED STATES Robert F. LaPrade, MD, PhD, UNITED STATES
Surgical Timing Does Not Interfere On Clinical Outcomes In Combined Reconstruction Of The Anterior Cruciate Ligament And Anterolateral Ligament: A Comparative Study With Minimum 2-Year Follow-Up ePoster Presentation Camilo P. Helito, MD, PhD, Prof, BRAZIL Marcel F. Sobrado, MD, PHD, BRAZIL Pedro N. Giglio, MD, BRAZIL Marcelo B. Bonadio, MD, BRAZIL Riccardo Gomes Gobbi, MD, PhD, BRAZIL José R. Pécora, Prof., BRAZIL Gilberto L. Camanho, MD, BRAZIL
Association Between Meniscal Allograft Tears and Early Surgical Meniscal Allograft Failure Award Winner Philipp Wilhelm Winkler, MD, Assoc. Prof., AUSTRIA Nyaluma N. Wagala, MD, UNITED STATES Jonathan D Hughes, MD, PhD, UNITED STATES James J. Irrgang, PT, PhD, FAPTA, UNITED STATES Freddie H. Fu, MD, UNITED STATES

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Osteoarthritis-Biomarkers Behavior in Patients with ACL-Reconstruction, at 2 Years Follow Up.

Osteoarthritis-Biomarkers Behavior in Patients with ACL-Reconstruction, at 2 Years Follow Up.