2019 ISAKOS Biennial Congress ePoster #963
Efficacy of Repeated Administration of One-Gram Intravenous Acetaminophen Injection for Pain Management After Total Knee Arthroplasty
Kazushige Seki, MD, Ube, Yamaguchi JAPAN
Hiroyoshi Ogasa, PhD, Ube, Yamaguchi JAPAN
Atsunori Tokushige, MD, Ube, Yamaguchi JAPAN
Takashi Imagama, PhD, Ube, Yamaguchi JAPAN
Toshihiro Seki, MD, Ube, Yamaguchi JAPAN
Takashi Sakai, Prof., Ube, Yamaguchi JAPAN
Dept. of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, JAPAN
FDA Status Cleared
Summary
The aim of this study was to evaluate the efficacy of intravenous acetaminophen for total knee arthroplasty. The NRS pain score at 12 and 18 hours after total knee arthroplasty was significantly better in the intravenous acetaminophen group than the control group. Intravenous acetaminophen is effective in significantly reducing pain following primary total knee arthroplasty.
Abstract
Background
The use of intravenous acetaminophen has seen one component of a multimodal approach to pain management. However, there is few literature of efficacy of intravenous acetaminophen for pain control in total knee arthroplasty in Japanese patients. The aim of this retrospective study was to evaluate the efficacy of intravenous acetaminophen for total knee arthroplasty.
Methods
A total of 53 patients undergoing primary total knee arthroplasty at our institution were received 1 gram of intravenous acetaminophen every 6 hours for 24 hours postoperatively. A control group of fifteen patients who had undergone primary total knee arthroplasty at our institution. They received no intravenous acetaminophen postoperatively. The primary outcome was the postoperative Numerical Rating Scale (NRS) pain score at the time of administration of study drugs. And we evaluated patient’s satisfaction at 24hours postoperatively. Patients were asked to grade their level of satisfaction for each question (i.e. ‘very dissatisfied’, ‘dissatisfied’, ‘neutral’, ‘satisfied’ or ‘very satisfied’).
Results
The score at 6 and 24 hours after total knee arthroplasty was no significant in the intravenous acetaminophen group than the control group (6hours: 2.2±2.6 vs 2.7±1.8, 24hours: 2.8±2.2vs 3.8±2.1). However, the score at 12 and 18 hours was significantly better in the intravenous acetaminophen group than the control group (12hours: 2.1±2.6 vs 4.2±2.9 p<0.05, 18hours: 2.6±2.6 vs 4.8±2.4 p<0.01). And there was a significant difference in the number of patients who answered ‘satisfied’ or ‘very satisfied’ between the two groups (62.5% in the intravenous acetaminophen group vs. 20% in control group, p<0.01).
Conclusion
Intravenous acetaminophen is effective in significantly reducing pain following primary total knee arthroplasty in Japanese patients.