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Incidence and Prevention of Deep Vein Thrombosis Using Thromboprophylaxis in Total Knee Replacement: A Prospective Clinical Study

2023 Congress Paper Abstracts
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Incidence and Prevention of Deep Vein Thrombosis Using Thromboprophylaxis in Total Knee Replacement: A Prospective Clinical Study

Amit Lakhani, MS, DNB, MRCPS(Glassg), MNAS, INDIA

maharishi markandeshwar medical college and hospital , kumarhatti, Himachal pradesh, INDIA


2023 Congress   ePoster Presentation   2023 Congress   Not yet rated

 

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Summary: though DVT events despite prophylaxis reflect questions about the preventability of post-injury DVT. But in this clinical study Mechanical prophylaxis as an adjunct to Pharmacologic prophylaxis’s helps in reduction of incidence of DVT significantly


Purpose

-Deep vein thrombosis (DVT), a common type of venous thrombosis, and its complication, pulmonary embolism (PE), can be life threatening. It is associated with increased morbidity and mortality. The association between total knee replacement(TKR) and Venous thromboembolism (VTE) has been recognized for almost a century. After a TKR, the incidence of VTE varies from 7% to 58%, depending on patient demographics, mechanism of injury, diagnoses, and type of VTE prophylaxis used
Different types of VTE prophylaxis used are mechanical or pharmacologic. Supported by high-quality evidence, pharmacologic thromboprophylaxis is recommended for high risk trauma patients . This prospective study was done with a primary aim to determine the incidence and nature of DVT in TKR patients and also to assess the superiority of mechanical thromboprophylaxis+ pharmacologic prophylaxis’s as compared pharmacologic prophylaxis’s on the incidence of DVT in lower limb trauma patients
Methods- This prospective observational study included 336 patients age 58 years or older who presented with TKR admitted into the orthopaedic unit. Those filling inclusion criteria underwent lower-limb Colour doppler ultrasound at 48 hrs than 1 week during their hospital course to diagnose DVT further follow up ultrasound depend upon the clinical signs . Based on Venous Thromboembolism ( VTE ) Risk assessment tool and bleeding Risk assessment Group 1 was given mechanical prophylaxis in form of an intermittent pneumatic compression device (IPC) along with pharmacologic prophylaxis ( low-molecular-weight heparin (LMWH) or unfractionated heparin (UFH) and Group 2 was given pharmacologic prophylaxis alone.

Results

A total of 336 patients underwent extremity Doppler ultrasound to detect DVT and were given. VTE prophylaxis based in injury severity score.
Group 1 : Total 164 patients received ( IPC+ LMWH) and only 3 ( 1.82%) patients developed DVT
Group 2: Total 172 patients (LMWH) and 24 (13.9%) patient develop DVT despite prophylaxis’s

Group 1 vs Group 2 shows significant difference with P value < 0.05. Over all incidence of DVT detected in both groups are 8.04% and proximal DVT 23(6.84%) and only 4 distal DVT (1.19%) patients showed recanalization within 3 months post operatively without single episode of PE. Prevalent DVT was not detected in any patients. Overall, no in-hospital deaths were related to DVT and/or PE.
Hence it can be concluded that though DVT events despite prophylaxis reflect questions about the preventability of post-injury DVT. But in our preventive clinical study Mechanical prophylaxis as an adjunct to Pharmacologic prophylaxis’s helps in reduction of incidence of DVT significantly so we recommend the usage of IPC along with Pharmacological prophylaxis in patients of total knee replacement.


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