2025 ISAKOS Biennial Congress ePoster
Acellular Particulated Costal Allocartilage Improves Cartilage Regeneration In High Tibial Osteotomy: Data From A Randomized Controlled Trial
Jusung Lee, MD KOREA, REPUBLIC OF
Sung-Hwan Kim, MD, PhD, Seoul KOREA, REPUBLIC OF
Min Jung, MD, PhD, Seoul KOREA, REPUBLIC OF
Hyun-Soo Moon, MD, PhD, Seoul KOREA, REPUBLIC OF
Se-Han Jung, MD, Seoul KOREA, REPUBLIC OF
Kwangho Chung, MD, Seoul KOREA, REPUBLIC OF
Yonsei University College of Medicine, seoul, KOREA, REPUBLIC OF
FDA Status Cleared
Summary
Microfractures combined with acellular particulated costal allocartilage led to superior repair quality compared to microfractures alone at a minimum 2-year follow-up after high tibial osteotomy (HTO). However, the functional outcomes improved in a similar manner for both treatment methods.
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Abstract
Objective
This study aimed to compare short-term arthroscopic and clinical outcomes between microfractures with (treatment group) and without (control group) acellular particulated costal allocartilage in patients undergoing concurrent high tibial osteotomy (HTO).
Design: This retrospective cohort study enrolled 19 and 21 patients in the treatment and control groups, respectively, and reviewed them at a minimum 2-year follow-up after HTO. Cartilage regeneration status was evaluated according to the International Cartilage Repair Society–Cartilage Repair Assessment (ICRS-CRA) grading and Koshino’s macroscopic staging systems during medial locked plate removal. Patient-reported measures, including the visual analog scale pain score, Knee Injury and Osteoarthritis Outcome Score, and International Knee Documentation Committee score, assessed clinical outcomes.
Results
The total points of the ICRS-CRA grading system were significantly higher in the treatment group than in the control group (7.7±3.8 vs 4.2±3.0, respectively; P=0.007). Likewise, the cartilage status according to Koshino’s macroscopic staging system was better in the treatment group (P=0.022). Patient-reported functional outcomes significantly improved postoperatively but were equivalent between the study groups at the final follow-up.
Conclusions
Microfractures augmented with acellular particulated costal allocartilage resulted in better repair quality than microfractures alone at a minimum 2-year follow-up after HTO, but functional outcomes improved similarly for both treatment approaches.