2023 ISAKOS Biennial Congress ePoster
Anterior Cruciate Ligament Reconstruction Alongside Mesenchymal Stem Cells Implantation Improves Knee Function in a Long-Term Follow-Up
Theofylaktos Kyriakidis, MD, MSc, PhD, Thessaloniki, Europe GREECE
Ioannes Melas, Thessaloniki GREECE
Alexandros Panagiotis Tzaveas, MD, Thessaloniki GREECE
Efstathios Michalopoulos, PhD, Athens GREECE
Michail I. Iosifidis, MD, PhD, Thessaloniki GREECE
3rd Orthopaedic Department Interbalkan Medical Center, Thessaloniki, GREECE
FDA Status Cleared
Summary
ACL associated with Mesenchymal stem cells improves knee function
ePosters will be available shortly before Congress
Abstract
Purpose
The present prospective study aims to evaluate the long-term results after matrix-induced autologous mesenchymal stem cells (MSCs) implantation alongside Anterior Cruciate Ligament (ACL) reconstruction.
Methods
20 ICRS grade 3 and 4 cartilage lesions (mean size 4.9 cm2) in 20 patients (mean age 29.06 years) were treated with a single-staged procedure involved filling of each defect with autologous culture-expanded AD-MSCs embedded in a trimmed-to-fit biodegradable matrix. The patients were followed at 1st, 3rd and 6th p.o. year using the Knee injury and Osteoarthritis Outcome Score (KOOS) and the International Knee Documentation Committee (IKDC) forms. The patients were divided in 2 groups according to the concomitant ACL lesion. Patients in group A (N=9) had MSCs implantation and ACL reconstruction, and group B (control group) (N=11), had only MSCs implantation. Linear mixed effects models were employed to determine the association of scores in each scale with the group of patients (with or without ACL), time, and their interaction.
Results
On the average, the rate of (linear) improvement from pre-operative to 6th year FU was not statistically significantly different between the two groups regarding all scales except from KOOS ADL (p=.006) and KOOS QoL (p=.018). The rate of improvement in KOOS ADL scale from pre-operative to 6th year FU for patients in group without ACL was higher than that of patients with ACL. The rate of improvement in KOOS QoL scale from pre-operative to 6th year FU for patients in group without ACL was lower than that of patients with ACL. It was also recorded better scores in ACL plus MSCs group in IKDC and KOOS pain scales.
Conclusions
The present study has shown significant improvement for both groups over time. Interestingly, the ACL plus MSCs implantation group A showed relatively better improvement during p.o. time for IKDC score and pain sub-scale.
Key words: Cartilage Lesions, Mesenchymal Stem Cells, ACL reconstruction