2017 ISAKOS Biennial Congress ePoster #236
Postoperative 2 Years Follow-Up Of Matrix Induced Autologous Chondrocyte Implantation In 67 Cases
Weimin Zhu, MD, Shenzhen, Guangdong CHINA
Wei Lu, MD, PhD, Prof., Shenzhen, Guangdong CHINA
Jiaming Cui, MB, PhD, Chengdu, Sichuan CHINA
Shenzhen Second People's Hospital, Shenzhen, Guangdong, CHINA
FDA Status Not Applicable
Summary
clinical results of two-year follow-up study affirmed that MACI technique
ePosters will be available shortly before Congress
Abstract
Objective
To evaluate the safety and efficacy of matrix-induced autologous chondrocytes implantation treatment ( MACI, Genzyme, America) for patients suffering from cartilage lesions of knee in a follow-up study for two years.
Methods
MACI operation was performed in a total of 67 patients, with an average age of 34.9 years and average defect size of 4.51 cm2 from 2012 to 2014. The procedure of MACI began with harvesting cartilage tissue which obtained from autologous nonweight-bearing region for proliferation in vitro. The cultivated chrondrocytes were seeded onto type ?/type ? collagen bilayer membrane which was glued by fibrin sealant to cartilage defect area after suitable shaped. Knee injury and Osteoarthritis Outcome Score ( KOOS) and Magnetic resonance imaging ( MRI) were used to evaluate clinical rehabilitation in three, six, 12 and 24months postoperatively. In addition, three arthroscopic look and two histological examinations were performed post-surgery.
Results
There were no postoperative complications in all patients and no adverse events related with MACI operation. Three months after operation, evaluation of KOOS in pain showed significant improving compared with baseline (P<0.05). Six months after surgery, KOOS results demonstrated significant improvement (P<0.05) in pain, symptoms, activities of daily life ( ADL), sports and recreation functions, and other knee-related QOL ( quality of life). MRI exhibited that new generated cartilage completely filled defect regions. Postoperative MRI in 12 and 24 months presented significant improving in defect filling, integration, signal intensity and subchondral bone.Postoperative histological evaluation of 12 and 24 months presented the predominate hyaline cartilage in new generated tissue.MACI operation time was controlled within two hours with less than 100 ml bleeding.
Conclusion
Our clinical results of two-year follow-up study affirmed that MACI technique was a safe, reliable and valid treatment for cartilage lesions with characteristics of noncomplicated technique, short operating time and small amount of surgical bleeding.