2017 ISAKOS Biennial Congress IFOSMA ePoster #5027
Comparison of Magnetic Resonance Imaging with Histological on the Degeneration of Meniscus
Zhongzheng Li, MD, Ningbo, Zhejiang CHINA
Zhenzhu Fang, MD, PhD, Ningbo, Zhejiang CHINA
NingBo NO.9 Hospital,, ningbo, zhejiang, china
FDA Status Not Applicable
Summary
The Severities of meniscus degeneration on MRI and pathological histological findings are inconsistent, so according MRI to determine the degree of meniscus degeneration need to pay attention.
Abstract
Purpose
The purpose of this study was to investigate the relationship between MRI and histopathological changes on the degeneration of Meniscus.
Methods
The meniscus from knees with osteoarthritis undergoing total knee arthroplasty (study group) and five from arthrocopic controls (control group) were accepted arthrocopic operation. Degeneration severities of the menisci were graded using MRI, histologic examinations of the menisci were then performed. Comparative analyses of MRI grading and results of histological examinations of the menisci were performed in each group. In addition, comparative analyses of histological were performed between specimens of the study group and the control group.
Results
All specimens from the control group showed grade 0 on MRI and their histology was also grade 0. In addition, no significant differences in biochemical results were observed among the specimens of the control group. In the lateral meniscus from the study group showing degeneration on MRI it was found that the water and proteoglycan contents increased with increasing grade of degeneration whereas the collagen content decreased. The meniscus specimens of the control group and the study group showing grade 0 on MRI had similar histologic findings but had different biochemical properties. The grade I, II degenerations on MRI were not well matched with the histologic findings in the study group.
Conclusion
The Severities of meniscus degeneration on MRI did not well reflect the histologic findings of the meniscus. The factors of the high signal intensity of the degenerated lateral meniscus on MRI may be due to the decreased component of collagen and increased proteoglycan. Our findings suggested that caution should be taken when the severities of meniscus degeneration on MRI are attributed to histologic severities of degenerated meniscus.