2015 ISAKOS Biennial Congress ePoster #2618

BMP4 and FGF3 Haplotypes Increase the Risk of Tendinopathy in Volleyball Athletes

Rodrigo Araujo Góes, MD, Niteroi, Rio de Janeiro BRAZIL
Julie Calixto Lobo, PhD, Niteroi, RJ BRAZIL
Priscila Ladeira Casado, PhD, Niteroi, RJ BRAZIL
José Inacio Salles, PhD, Rio De Janeiro, RJ BRAZIL
Marcus Vinicius Galvão Amaral, MD, Rio de Janeiro BRAZIL
Diego Pinheiro Aguiar, PhD, Rio De Janeiro, RJ BRAZIL
Daisy Anne Lira, PhD, Rio De Janeiro, RJ BRAZIL
Valquiria Quinelato, PhD, Rio De Janeiro, RJ BRAZIL
Maria Eugenia Duarte, PhD, Rio De Janeiro, RJ BRAZIL
Letícia Ladeira Bonato, PhD, Rio De Janeiro, RJ BRAZIL
Alexandre Rezende Vieira, PhD, Rio De Janeiro, RJ BRAZIL

Instituto Nacional de Traumatologia e Ortopedia, Rio de Janeiro, Rio de Janeiro, BRAZIL

FDA Status Not Applicable

Summary: BMP4 and FGF3 haplotypes increase the risk of tendinopathy in volleyball athletes. A significant association between BMP4 rs2761884 (p=0.03) and tendinopathy was observed. Athletes with a polymorphic genotype have 2.4 times more susceptibility to tendinopathy (OR=2.39; 95%CI=1.10-5.19).

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Abstract:

Objectives: To investigate whether genetic variants can be correlated with tendinopathy in elite male volleyball athletes. Methods: Fifteen single nucleotide polymorphisms within BMP4, FGF3, FGF10, FGFR1 genes were investigated in 138 elite volleyball athletes, aged between 18 and 35 years, who undergo 4-5h of training per day: 52 with tendinopathy and 86 with no history of pain suggestive of tendinopathyin patellar, Achilles, shoulder, and hip abductors tendons. The clinical diagnostic criterion was progressive pain during training, confirmed by magnetic resonance image. Genomic DNA was obtained from saliva samples. Genetic markers were genotyped using TaqMan real-time PCR. Chi-square test compared genotypes and haplotype differences between groups. Multivariate logistic regression analyzed the significance of covariates and incidence of tendinopathy. Resuts: Statistical analysis revealed participant age (p=0.005) and years of practice (p=0.004) were risk factors for tendinopathy. A significant association between BMP4 rs2761884 (p=0.03) and tendinopathy was observed. Athletes with a polymorphic genotype have 2.4 times more susceptibility to tendinopathy (OR=2.39; 95%CI=1.10-5.19). Also, association between disease and haplotype TTGGA in BMP4 (p=0.01) was observed. The FGF3 TGGTA haplotype showed a tendency of association with tendinopathy (p=0.05), and so did FGF10 rs900379. FGFR1 showed no association with disease. Conclusion: These findings indicate that haplotypes in BMP4 and FGF3 genses may contribute to the tendon disease process in elite volleyball athletes.