General Objectives: To enhance participants’ knowledge and application of the latest updates, trends, and future directions in the prevention, diagnosis, and treatment of prosthetic knee joint infections.

Specific Objectives: By the end of this symposium, participants will be able to: - Analyze global trends in periprosthetic joint infections (PJIs), including the rising incidence of multidrug-resistant (MDR) infections. - Understand the challenges of diagnosing polymicrobial infections and explore recent advancements in diagnostic technologies, including biomarkers, molecular-based, and culture-based methods. - Explain the role of prophylactic antibiotics in preventing PJIs, including optimal timing, selection, and dosing based on patient characteristics and surgical factors. - Gain insights into the role of artificial intelligence (AI) in PJI management, particularly in predicting the success rates of procedures like DAIR (Debridement, Antibiotics, and Implant Retention). - Outline evidence-based treatment strategies for managing infected TKA, from classic approaches to novel treatment modalities, and determine the appropriate strategy for each case.