2017 ISAKOS Biennial Congress ePoster #233

 

The Effect Of Hyaluronic Acid And Platelet Rich Plasma In The Repair Capacity Of Articular Cartilage In An Animal Model Of Chondral Lesions.

David Figueroa, MD, Prof., Santiago, RM CHILE
Rafael Calvo, MD, Santiago CHILE
Rafael Martinez, MD, PhD, Santiago, Region Metropolitana CHILE
Francisco Figueroa, MD, Santiago, RM CHILE
Alex Vaisman, MD, Prof., Santiago, RM CHILE
Sergio Arellano, MD, Santiago, Region Metropolitana CHILE

ClĂ­nica Alemana - UDD, Santiago, RM, CHILE

FDA Status Cleared

Summary

PRP infiltration showed to enhance the regeneration capacity of the tissue after an OCL. Contrarily, HA infiltration slowed the repair process. These results raise questions over the clinical election of the different available adjuvant intra-articular therapies

Abstract

Objectives
Hyaluronic acid (HA) and platelet-rich plasma (PRP) are used in clinical practice as adjuvants for the management of osteochondral lesions (OCLs), however the present evidence of their histological effect is limited. The objective of this study is to determine the effect of HA and PRP in the regenerating capacity of OCLs in an animal model.

Methods

Experimental study. Twenty-four BKS mice underwent the same OCL (0,5mm diameter over the trochlear groove) and were randomly divided into three treatment groups: Group A: control (8 mice - 16 knees); Group B: intra-articular infiltration with HA (8 mice - 16 knees); Group C: intra-articular infiltration with PRP (8 mice - 16 knees). Assessment of cartilage repair was made (at 7 days) using the International Cartilage Repair Society II (ICRS-II) grading system. Statistical analysis included ANOVA test.

Results

Group A: ICRS-II average score 9.75 (9-11); Group B: ICRS-II average score 5.25 (4-7); Group C: ICRS-II average score 15.5 (13-18). There is statistical difference between all groups: A and B; B and C; A and C (p<0,01).

Conclusions

In a murine experimental model, PRP infiltration showed to enhance the regeneration capacity of the tissue after an OCL. Contrarily, HA infiltration slowed the repair process. These results raise questions over the clinical election of the different available adjuvant intra-articular therapies.