2017 ISAKOS Biennial Congress ePoster #1284

 

Platelet-rich plasma (PRP) applied during total knee arthroplasty

João P.F. Guerreiro, MD, PhD, Londrina, Parana BRAZIL
Marcus Vinicius Danieli, MD, PhD, Londrina, Parana BRAZIL
João P.F. Guerreiro, MD, PhD, Londrina, Parana BRAZIL
Elenice Deffune, PhD, Botucatu, São Paulo BRAZIL
Rosana Rossi Ferreira, PhD, Botucatu, Sao Paulo BRAZIL

UNIORT.E/Santa Casa de Londrina, Londrina, Parana, BRAZIL

The FDA has not cleared the following pharmaceuticals and/or medical device for the use described in this presentation. The following pharmaceuticals and/or medical device are being discussed for an off-label use:

Summary

A blinded randomized controlled clinical study to evaluate efficacy of platelet-rich plasma regarding healing, pain and hemostasis after total knee arthroplasty.

Abstract

Objective

To evaluate the efficacy of platelet-rich plasma regarding healing, pain and hemostasis after total knee arthroplasty, by means of a blinded randomized controlled and blindedclinical study.Methods: Forty patients who were going to undergo implantation of a total knee prosthesiswere selected and randomized. In 20 of these patients, platelet-rich plasma was applied before the joint capsule was closed. The hemoglobin (mg/dL) and hematocrit (%) levels were assayed before the operation and 24 and 48 hours afterwards. The Womac questionnaire and a verbal pain scale were applied and knee range of motion measurements were made up to the second postoperative month. The statistical analysis compared the results with the aim of determining whether there were any differences between the groups at each of the evaluation times. Results: The hemoglobin (mg/dL) and hematocrit (%) measurements made before the operation and 24 and 48 hours afterwards did not show any significant differences between thegroups (p>0.05). The Womac questionnaire and the range of motion measured beforethe operation and up to the first two months also did not show any statistical differences between the groups (p>0.05). The pain evaluation using the verbal scale showed thatthere was an advantage for the group that received platelet-rich plasma, 24 hours, 48 hours,one week, three weeks and two months after the operation (p<0.05).Conclusions: In the manner in which the platelet-rich plasma was used, it was not shown tobe effective for reducing bleeding or improving knee function after arthroplasty, in comparison with the controls. There was an advantage on the postoperative verbal pain scale.