2017 ISAKOS Biennial Congress ePoster #1201

 

Comparison of Topical and Intravenous Tranexamic Acid on Efficacy and Safety in Primary Total Knee Arthroplasty, a Meta-Analysis

Hongtao Xu, MD, Shijiazhuang, Hebei CHINA
Jiangtao Dong, MD, Shijiazhuang, Hebei CHINA
Baicheng Chen CHINA

The Third Hospital of Hebei Medical University, Shijiazhuang, CHINA

FDA Status Cleared

Summary

We conclude that topical TXA is similar to intravenous TXA in efficacy and safety.

Abstract

Purpose

Tranexamic acid (TXA) has been confirmed to reduce blood loss in primary total knee arthroplasty (TKA) successfully according to abundant randomized controlled trials. But we are not clear whether topical TXA is more effective or safer than intravenous. The purpose of this study is to undertake a meta-analysis to explore whether topical TXA carried similar efficacy and safety with intravenous TXA in TKA.

Method

The auther enrolled high quality randomized controlled trials with Jadad score and analysed the outcome of postoperative hemoglobin drop, total drain output, blood loss, blood units transfused per patient, transfusion requirement, and complications. Subgroup analysis was performed when possible.

Results

This meta-analysis comprising 1328 patients from eight eligible reports indicated that there was no statistically significant difference in Max Hb drop (48h) Total drain output, Total blood loss, Transfusion requirements, Thromboembolic complications when camparing topical and intravenous regimen of TXA in primary TKA, but there was statistically significant difference in Max Hb drop (24h).

Conclusion

We conclude that topical TXA is similar to intravenous TXA in efficacy and safety except for Max Hb drop (24h), which means although there is not much difference in two kind of regimen of TXA, topical TXA show more Efficacy in 24h after TKA.