Page 36 -

YOUNG INVESTIGATOR’S SCHOLARSHIP & RESEARCH MENTORING PROGRAM REPORTS
ISAKOS Young Investigator’s Scholarship & Research Mentoring Program
Report from Lyon
The ISAKOS Young Investigator’s Scholarship and Research Mentoring Program was developed by the ISAKOS Scientific Committee as a mentor-mentee program for young investigators with specific focus on developing countries. The Young Investigator Program seeks to stimulate research and education in developing countries, foster international collaboration, and promote academic excellence in arthroscopy, knee surgery and orthopaedic sports medicine.
The first group of Young Investigators were selected in early 2015 and invited to attend the ISAKOS Congress in Lyon, France. These are their personal accounts of their experiences.
Tiago Lazzaretti Fernandes, MD, MSc, PhD “’in process’’, BRAZIL
I’m thankful for ISAKOS Young Investigator’s Research Program, as it was a great opportunity to update my knowledge and improve technical skills related to a variety of topics!
• Knee laxity and rotation measurement of ACL deficient knee
• Importance of anterolateral compartment for rotational stability
• Concept of ACL remnant and ACL reconstruction outcome; ACL deficient knee associated with cartilage lesion
• Tissue engineering and cell therapy related to cartilage and ACL injury
Knee Laxity Measurement and Lateral Compartment
Prof. João Espregueira-Mendes headed a good discussion about knee kinematic measurements with Dr. Volker Musahl, Dr. Andrew Pearl and other colleagues.
Tracking pivot shift using invasive and non-invasive navigation systems and knee testing devices were shown to be adequate tools to quantify pivot magnitude. Authors demonstrated that these technologies were capable to evaluate and predict clinical outcomes for ACL deficient knees.
Another relevant topic was related to static and dynamic ACL deficient knee measurements of lateral tibial plateau. These devices presented a higher AP translation of lateral compartment with Lachman and pivot shift tests, which could be associated with iliotibial band transection, lateral meniscectomy, osseous conformity, capsule and extra-articular ligaments.
Other presenters also emphasized the importance of periphery or extra-articular components to restrain internal rotation in ACL reconstruction, as Hughston et al. described in 1979 lateral structures.
ACL Remnants and Clinical Outcomes
ACL remnant was also in highlight in the 10th Biennial ISAKOS Congress. Some authors presented data showing that 22.7% of ACL deficient knees have normal femoral insertion site. According to Nakase et al. (KSSTA, 2013) type III remnants contributed to AP and rotatory laxity control at 300.
Presenters concluded that preservation of ACL remnants during reconstruction should contribute to knee stability, better graft revascularization and less tunnel enlargement. However, clinical outcome was not presented as different yet.
ACL Deficient Knee and Associated Lesions
The last, but not the least, topic of interest is discussed here. Professor Norimasa Nakamura and Professor Alberto Gobbi led a Symposium about cartilage and ACL injury treatment with regenerative medicine. After torn ACL, serum biomarkers for cartilage lesion increases. It shows the importance to treat these associate lesions due to osteoarthritis.
It was presented that stem cells and scaffold tissue engineering could be a future possibility for treating these concomitant lesions. Some sort of induced pluripotent cells were presented for cartilage regeneration (Yamashita, 2015)
In another Symposium, Professors João Espregueira-Mendes and Stephano Zaffagnini discoursed about chondroprotective effect of biomaterials as tissue engineered scaffolds and allografts.
34 ISAKOS NEWSLETTER 2015: Volume II