2021 ISAKOS Biennial Congress ePoster
Autologous Matrix-Induced Chondrogenesis (Amic) For Isolated Retropatellar Cartilage Lesions: Outcome After A Follow-Up Of Minimum Two Years
Manuel Waltenspül, MD, Zürich SWITZERLAND
Cyrill Suter, MD, Zürich SWITZERLAND
Jakob Ackermann, MD, Zurich SWITZERLAND
Nathalie Kühne, SN, Zürich SWITZERLAND
Sandro Fucentese, Prof MD, Zuerich, CH SWITZERLAND
Balgrist University Hospital, Zürich, 8008, SWITZERLAND
FDA Status Cleared
Summary
AMIC for retropatellar cartilage lesions in combination with concomitant corrective surgery for patellar instability results in low failure rate with satisfactory clinical outcome
ePosters will be available shortly before Congress
Abstract
Purpose
To evaluate autologous matrix-induced chondrogenesis (AMIC) for isolated focal retropatellar cartilage lesions and the influence of patellofemoral (PF) anatomy on clinical outcomes at a minimum of 2-year follow-up.
Methods
Twenty-nine consecutive patients (31 knees) that underwent retropatellar AMIC with a mean age of 27.9 +/- 11.0 years were evaluated at a follow-up averaging 4.1 +/- 1.9 (range, 2 to 8) years. Patient factors, lesion morphology and patient-reported outcome measures including KOOS, Tegner, Kujula score and VAS score were collected. PF anatomy was assessed on pre- and postoperative imaging, and subsequently correlated to outcome scores and failure to determine risk factors for poor outcome.
Results
At final follow-up, the AMIC graft failed in 4 cases (12.9%) at a mean follow-up of 21 +/- 14.1 months. Patients with failed grafts had a significantly smaller patellar and Laurins' PF angle than patients whose graft did not fail (p=0.008 and p=0.004, respectively). Concomitant corrective surgery for patellar instability was performed in 29 knees (93.5%). Grafts that did not fail presented with an average Kujala score of 71.3 +/-16.9, KOOS of 68.7 and Tegner scores of 4.2 +/- 1.8. The patellar angle was significantly associated with the patient’s satisfaction level (r=0.615; p<0.001).
Conclusion
AMIC for retropatellar cartilage lesions in combination with concomitant corrective surgery for patellar instability results in low failure rate with satisfactory clinical outcome and patient satisfaction of almost 80% at mid-term follow-up. Smaller patellar and Laurins' PF angle are associated with less favorable outcome.