Summary

Surgical Factors at the Time of Revision ACL Reconstruction Impact Outcome in the MARS cohort at 6 years following revision reconstruction.

Abstract

Objectives:
Revision ACL reconstruction has been documented to have inferior outcomes compared with primary ACL reconstructions. The reasons why remain unknown. The purpose of this study was to determine if surgical factors performed at the time of ACL revision reconstruction has the ability to influence a patient’s outcome at 6-year follow-up.

Methods

Revision ACL reconstruction patients were identified and prospectively enrolled between 2006 and 2011. Data collected included baseline demographics, surgical technique and pathology, and a series of validated patient-reported outcome instruments (IKDC, KOOS, WOMAC, and Marx activity rating score). Patients were followed up for 6 years and asked to complete the identical set of outcome instruments.
Regression analysis was used to control for age, gender, BMI, activity level, baseline outcome scores, revision number, time since last ACLR, and a variety of surgical variables, in order to assess the surgical risk factors for clinical outcomes 6 years after revision ACL reconstruction.

Results

1234 patients met the inclusion criteria and were successfully enrolled. 716 (58%) were males, with a median cohort age of 26 years. The median time since their last ACL reconstruction was 3.3 years.

At 6 years, follow-up was obtained on 77% (949/1234). Several surgical factors at the time of revision surgery were found to be significant drivers of poorer outcomes at 6 years. The most consistent surgical variables driving outcome in revision patients were related to femoral and tibial fixation. Using an interference screw for femoral fixation compared with a cross-pin resulted in significantly better outcomes in 6-year IKDC scores (OR=2.2 p=0.008), KOOS sports/rec and KOOS QOL subscales (OR range = 2.2-2.7 p<0.001). Using an interference screw compared with a cross-pin also resulted in 2.6 times less likely to have a subsequent surgery within the 6 years.

Using an interference screw for tibial fixation compared to any combination of tibial fixation techniques also resulted in significantly improved IKDC (OR=2.0; 95% CI=1.3, 2.9; p=0.001), KOOS pain, ADL, sports/rec (OR range=1.5-1.6; 95% CI=1.0, 2.4; p<0.05) and WOMAC pain and stiffness subscales (OR range=1.5-1.8; 95% CI=1.0, 2.9; p<0.05).

Using a transtibial surgical approach compared to an anteromedial portal approach resulted in significantly improved KOOS pain and QOL subscales at 6 years (OR=1.5; 95% CI=1.02, 2.2; p<0.04).

Avoiding a notchplasty significantly improved 2 year outcomes of the IKDC (OR=1.5; 95% CI=1.1, 2.0; p=0.013), KOOS ADL and QOL subscales (OR range= 1.4; 95% CI=1.0, 1.9; p<0.04), and the WOMAC stiffness and ADL subscales (OR range = 1.4-1.5; 95% CI=1.0, 2.1; p<0.04).

Regarding tunnel position at the time of the revision surgery, surgeons who noted that the tibial tunnel aperture position was in the ‘optimum position’ fared significantly worse in 6-year IKDC scores (OR=0.6; 95% CI=0.4, 0.8; p=0.003), Marx activity levels (OR=0.20; 95% CI=0.07, 0.6; p=0.005), KOOS symptoms, pain, sports/rec, and QOL subscales (OR range=0.56-0.68; 95% CI=0.38, 0.47; p<0.05), compared with surgeons who opted for either a blended new tunnel or noted that the previous tunnel had the same tunnel aperture, but ‘compromised position’.

Knee flexion angle at the time of graft fixation and biologic enhancement (i.e. PRP) did not influence 6-year outcomes in this revision cohort.