ISAKOS: 2019 Congress in Cancun, Mexico
ISAKOS

2019 ISAKOS Biennial Congress ePoster #703

 

Effects of Autologous Adipose-Derived Regenerative Cells in the Healing and Function of Anterior Cruciate Ligament Reconstruction

Eduard Alentorn-Geli, MD, PhD, MSc, FEBOT, FACGME, Barcelona SPAIN
Roberto Seijas-Vazquez, MD, PhD, Prof., Barcelona SPAIN
Xavier Cuscó, MD, Barcelona SPAIN
Gilbert Steinbacher, MD, Sant Just Desvern SPAIN
Pedro Alvarez-Diaz, MD, PhD, Prof., Barcelona SPAIN
David Barastegui, MD, Barcelona SPAIN
Jordi Catala, MD, Barcelona SPAIN
Jordi Navarro, MD, Barcelona SPAIN
Patricia Laiz, MD, BSc, Barcelona SPAIN
Montserrat Garcia-Balletbo, MD, PhD, Barcelona, Catalunya SPAIN
Ramon Cugat, MD, PhD, Barcelona SPAIN

Fundación García-Cugat, Barcelona, SPAIN

FDA Status Not Applicable

Summary

The addition of adipose-derived regenerative cells at the time of ACL reconstruction significantly improved healing and function at 12 months. However, this improvement was not statistically significant compared to a control group undergoing ACL reconstruction alone.

Abstract

Purpose

To compare the healing and clinical outcomes of anterior cruciate ligament (ACL) reconstruction between patients with or without intraoperative administration of adipose-derived regenerative stem cells (ADRC).

Methods

Between 2013 and 2014, the outcomes of 20 soccer players undergoing ACL reconstruction using bone-tendon-bont (BTB) autograft infiltrated with ADRC at the end of the procedure were compared to a historical, matched-cohort of 19 soccer players undergoing the same procedure without ADRC. Outcomes were obtained at baseline, and 6 and 12 months postop for IKDC, Lysholm, and Lequesne, and at 2, 4, 6, and 12 months postop for VAS for pain and graft maturation to evaluate the ligamentization process (MRI-based).

Results

Both groups significantly improved the IKDC (p<0.001 in both groups), Lysholm (p<0.001 in both groups), Lequesne index (p<0.001 in both groups), VAS for pain (p=0.002 for the ADRSC and p<0.001 for the control group), and MRI scores (p<0.001 in both groups) in the 12 months postop compared to baseline scores. However, there were no significant differences in the improvement of the outcomes between groups across time (p>0.05). All patients returned to sports after surgery, but 8 (40%) patients in the ADRSC and 13 (68.4%) patients in the control group had lower Tegner activity score at 12 months postop.

Conclusions

Patients receiving ADRCs at the time of ACL reconstruction significantly improved knee function and healing/maturation of the graft at 12 months. However, this improvement was not statistically significant compared to a control group undergoing ACL reconstruction alone.